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Temonat 100 mg Capsule
Temonat 100 mg
Capsule is an anticancer agent used in the treatment of certain types of brain
cancers. This medicine should be used with caution in patients with a known
history of hepatic and renal impairment. It is not recommended for use in
children under 3 years of age.
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Avoid being near people who are sick or have infections.
Consult your doctor if you develop symptoms of opportunistic infections (such
as Pneumocystis jirovecii pneumonia) and reactivation of infections (such as
hepatitis B virus) Using temozolomide may increase your risk of developing
certain types of bone marrow cancer. Be aware about your specific risk.
USES:
Temozolomide
is used for the treatment of anaplastic astrocytoma, glioblastoma multiforme
(GBM) (types of brain tumors). Temozolomide is classified as an alkylating
agent. Alkylating agents are most active
in the resting phase of the cell. These
drugs are cell-cycle non-specific. Temozolomide is similar to the drug
dacarbazine. It acts as a
"pro-drug" meaning it needs to be transformed to its active (cancer
fighting) form by the body's metabolism.
Dosage:
·
The recommended dose of temonat is usually once
daily for 5 days
·
The treatment may be repeated every 28 days
Overdose:
·
Symptoms of overdose associated with temonat may
include chills, persistent sore throat or persistent fever; or severe bleeding
or bruising
What are the side effects of Temonat 100 mg Capsule?
The following are the most common Temonat 100 mg side
effects
- · Nausea
- · Vomiting
- · Mouth sores
- · Constipation
- · Trouble sleeping
- · Changes in taste
- · Tiredness
- · Headache
- · Dizziness
The following are the severe side effects and you may
require immediate medical attention:
- · Chills
- · Seizures
- · Trouble breathing
- · Abdominal pain
- · Decreased white blood cell count
This is not a complete list of side effects and others may
occur. Please consult your doctor to know more about other possible side
effects.
Warnings
Warnings for special
population
Pregnancy - This
medicine is not recommended for use in pregnant women due to the increased risk
of fetal harm.
Breast-feeding -
This medicine is not recommended for use in breastfeeding women due to the
increased risk of severe adverse effects in the breastfed baby.
General warnings
Hepatotoxicity - Temonat 100 mg
Capsule should be used with caution in patients with a history of liver
disease due to the increased risk of severe adverse effects. Appropriate dose
adjustments or replacement with a suitable alternative may be required based on
the clinical condition.
Blood cell count
- This medicine should be used with caution due to the increased risk of very
low blood cell counts. Close monitoring of blood cell counts is necessary
during treatment with this medicine. Appropriate dose adjustments or
discontinuation of therapy may be required based on the clinical condition.
Impaired kidney
function - Temonat 100 mg Capsule should be used with caution in patients
with a history of kidney disease due to the increased risk of severe adverse
effects. Appropriate dose adjustments or replacement with a suitable
alternative may be required based on the clinical condition.
SAFETY INFORMATION:
Before taking temozolomide, tell your doctor or pharmacist
if you are allergic to it; or to dacarbazine; or if you have any other
allergies. This product may contain inactive ingredients, which can cause allergic
reactions or other problems. Talk to your pharmacist for more details.
STORAGE:
Store in a tightly closed container between 2-8°C.
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