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Temonat 100 mg Capsule
Temonat 100 mg Capsule is an anticancer agent used in the treatment of certain types of brain cancers. This medicine should be used with caution in patients with a known history of hepatic and renal impairment. It is not recommended for use in children under 3 years of age.

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Avoid being near people who are sick or have infections. Consult your doctor if you develop symptoms of opportunistic infections (such as Pneumocystis jirovecii pneumonia) and reactivation of infections (such as hepatitis B virus) Using temozolomide may increase your risk of developing certain types of bone marrow cancer. Be aware about your specific risk.

USES:
Temozolomide is used for the treatment of anaplastic astrocytoma, glioblastoma multiforme (GBM) (types of brain tumors). Temozolomide is classified as an alkylating agent.  Alkylating agents are most active in the resting phase of the cell.  These drugs are cell-cycle non-specific. Temozolomide is similar to the drug dacarbazine.  It acts as a "pro-drug" meaning it needs to be transformed to its active (cancer fighting) form by the body's metabolism.

Dosage:
·         The recommended dose of temonat is usually once daily for 5 days
·         The treatment may be repeated every 28 days

Overdose:
·         Symptoms of overdose associated with temonat may include chills, persistent sore throat or persistent fever; or severe bleeding or bruising

What are the side effects of Temonat 100 mg Capsule?
The following are the most common Temonat 100 mg side effects
  • ·         Nausea
  • ·         Vomiting
  • ·         Mouth sores
  • ·         Constipation
  • ·         Trouble sleeping
  • ·         Changes in taste
  • ·         Tiredness
  • ·         Headache
  • ·         Dizziness

The following are the severe side effects and you may require immediate medical attention:
  • ·         Chills
  • ·         Seizures
  • ·         Trouble breathing
  • ·         Abdominal pain
  • ·         Decreased white blood cell count

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

Warnings
Warnings for special population
Pregnancy - This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm.

Breast-feeding - This medicine is not recommended for use in breastfeeding women due to the increased risk of severe adverse effects in the breastfed baby.

General warnings
Hepatotoxicity - Temonat 100 mg Capsule should be used with caution in patients with a history of liver disease due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Blood cell count - This medicine should be used with caution due to the increased risk of very low blood cell counts. Close monitoring of blood cell counts is necessary during treatment with this medicine. Appropriate dose adjustments or discontinuation of therapy may be required based on the clinical condition.

Impaired kidney function - Temonat 100 mg Capsule should be used with caution in patients with a history of kidney disease due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

SAFETY INFORMATION:
Before taking temozolomide, tell your doctor or pharmacist if you are allergic to it; or to dacarbazine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

STORAGE:
Store in a tightly closed container between 2-8°C.


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